The effect of formulation and concentration of cholesteryl butyrate solid lipid nanospheres (SLN) on NIH-H460 cell proliferation.
Eur J Pharm Biopharm
; 52(2): 197-202, 2001 Sep.
Article
em En
| MEDLINE
| ID: mdl-11522486
ABSTRACT
Experimental factorial design was used to evaluate the influence of two factors involved in producing cholesteryl butyrate (chol-but) solid lipid nanospheres (SLN), microemulsion formulation and microemulsion/water ratio, on the effect of the SLN on the proliferation of NIH-H460, a non-small-cell lung carcinoma; six experimental settings were tested. The cells were treated with scalar concentrations of cholesteryl butyrate (from 0.008 to 1.000 mM) for each experimental condition; NIH-H460 cell growth was inhibited in all cases. The best experimental setting provided complete inhibition at 0.125 mM chol-but, while at the same concentration sodium butyrate provided only 38% inhibition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ésteres do Colesterol
/
Ácido Butírico
/
Antagonistas dos Receptores Histamínicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article