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A longitudinal study of lung transplant recipients infected with Aspergillus: genetic polymorphism of A fumigatus.
Symoens, F; Bertout, S; Piens, M A; Burnod, J; Renaud, F; Nolard, N; Chapuis, F; Grillot, R.
Afiliação
  • Symoens F; Scientific Institute of Public Health-Louis Pasteur, Mycology Section, Brussels, Belgium. f.symoens@iph.fgov.be
J Heart Lung Transplant ; 20(9): 970-8, 2001 Sep.
Article em En | MEDLINE | ID: mdl-11557192
BACKGROUND: Aspergillus infection is a well-known complication of lung transplantation and remains associated with high mortality rates. Molecular typing methods are required to elucidate the complex epidemiology of Aspergillus disease in lung transplant recipients. METHODS: Eight lung transplant recipients from one hospital were followed for A fumigatus colonization or infection. Forty-four sequential isolates from these patients were selected and typed by three molecular methods (random amplified polymorphic DNA, sequence-specific DNA primer and multi-locus enzyme electrophoresis). RESULTS: Sixteen different types were identified of which 14 were specific to 1 patient. A factorial correspondence analysis showed that variability between sequential isolates from a single patient was as high as between isolates from the other patients. Lung transplant recipients presented many different genotypes, reflecting the environmental diversity of A fumigatus. Nevertheless, throughout their follow-up, 2 of the 8 lung transplant recipients harbored a common genotype that was not replaced by others. CONCLUSIONS: These results confirm the important genetic polymorphism of the A fumigatus population. The observed genotypes were not related to the type of Aspergillus disease or anti-fungal treatment used nor to the outcome of the patient. These data confirm that all A fumigatus molecular types present the same pathogenic risk.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aspergilose / Transplante de Pulmão Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2001 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aspergilose / Transplante de Pulmão Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2001 Tipo de documento: Article