The nature of the bond between peptide and carrier molecule determines the immunogenicity of the construct.
J Pept Res
; 58(3): 237-45, 2001 Sep.
Article
em En
| MEDLINE
| ID: mdl-11576330
ABSTRACT
The influence of the nature of the bond between a peptide and a (lipidic) carrier molecule on the immunogenicity of that construct was investigated. As types of bonds a thioester-, a disulfide-, an amide- and a thioether bond were investigated. As carrier molecules a peptide, an N-palmitoylated peptide or a C(16)-hydrocarbon chain were used. The biostability of the bond between peptide and carrier molecule is thioether > amide > disulfide >> thioester. However, the immunogenic potency of the constructs used was found to be thioester > disulfide > amide > thioether. In conclusion, a construct with a bond between peptide and (lipidic) carrier molecule that is more susceptible to biological degradation is more immunogenic when used in a peptide-based vaccine than a bond that is less susceptible to biological degradation.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
/
Hormônio Liberador de Gonadotropina
/
Parvovirus Canino
/
Vacinas de Subunidades Antigênicas
/
Hidrocarbonetos
/
Anticorpos
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article