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Association of transforming growth factor-beta1 T29C polymorphism with the progression of diabetic nephropathy.
Akai, Y; Sato, H; Ozaki, H; Iwano, M; Dohi, Y; Kanauchi, M.
Afiliação
  • Akai Y; First Department of Internal Medicine, Department of Public Health, Nara Medical University, Kashihara, Japan. yakai@naramed-u.ac.jp
Am J Kidney Dis ; 38(4 Suppl 1): S182-5, 2001 Oct.
Article em En | MEDLINE | ID: mdl-11576951
ABSTRACT
Diabetes mellitus is a leading cause of end-stage renal disease in the Western world. Histologically, mesangial expansion with increased extracellular matrix protein is observed in patients with diabetic nephropathy. Because transforming growth factor (TGF)-beta promotes extracellular matrix production in response to high glucose, TGF-beta is considered to play a central role in the pathogenesis of diabetic nephropathy. We investigated the association of TGF-beta1 T29C polymorphism and the progression of diabetic nephropathy. Forty patients with type 2 diabetes mellitus were enrolled. All patients had had diabetes for more than 10 years. DNA was extracted from peripheral blood cells, and genotype was determined using real-time polymerase chain reaction method. Patients were classified into three groups according to genotype TT, TC, and CC. Grade of diabetic nephropathy was determined using the amount of urinary excretion of albumin. Demographic characteristics of the patients with each genotype were not statistically different. No differences in the glycemic control and the mode of therapy were observed. Among patients with three genotypes, the severity of diabetic nephropathy was not statistically different. The patients with TT genotype tended to have a higher rate of progression of nephropathy; however, no statistically significant difference was observed among the three groups. Our results suggest that TGF-beta1 T29C polymorphism is not associated with the progression of diabetic nephropathy. Further studies are required to determine the exact role of this polymorphism in the progression of diabetic nephropathy.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Transformador beta / Nefropatias Diabéticas Tipo de estudo: Risk_factors_studies Limite: Aged / Humans / Middle aged Idioma: En Ano de publicação: 2001 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Transformador beta / Nefropatias Diabéticas Tipo de estudo: Risk_factors_studies Limite: Aged / Humans / Middle aged Idioma: En Ano de publicação: 2001 Tipo de documento: Article