A role for MLH3 in hereditary nonpolyposis colorectal cancer.
Nat Genet
; 29(2): 137-8, 2001 Oct.
Article
em En
| MEDLINE
| ID: mdl-11586295
ABSTRACT
We investigated a possible role of the mismatch-repair gene MLH3 in hereditary nonpolyposis colorectal cancer by scanning for mutations in 39 HNPCC families and in 288 patients suspected of having HNPCC. We identified ten different germline MLH3 variants, one frameshift and nine missense mutations, in 12 patients suspected of HNPCC. Three of the 12 also carried a mutation in MSH6.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
/
Neoplasias Colorretais Hereditárias sem Polipose
Limite:
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article