Bayesian analysis of haplotypes for linkage disequilibrium mapping.
Genome Res
; 11(10): 1716-24, 2001 Oct.
Article
em En
| MEDLINE
| ID: mdl-11591648
ABSTRACT
Haplotype analysis of disease chromosomes can help identify probable historical recombination events and localize disease mutations. Most available analyses use only marginal and pairwise allele frequency information. We have developed a Bayesian framework that utilizes full haplotype information to overcome various complications such as multiple founders, unphased chromosomes, data contamination, and incomplete marker data. A stochastic model is used to describe the dependence structure among several variables characterizing the observed haplotypes, for example, the ancestral haplotypes and their ages, mutation rate, recombination events, and the location of the disease mutation. An efficient Markov chain Monte Carlo algorithm was developed for computing the estimates of the quantities of interest. The method is shown to perform well in both real data sets (cystic fibrosis data and Friedreich ataxia data) and simulated data sets. The program that implements the proposed method, BLADE, as well as the two real datasets, can be obtained from http//www.fas.harvard.edu/~junliu/TechRept/01folder/diseq_prog.tar.gz.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Haplótipos
/
Ataxia de Friedreich
/
Desequilíbrio de Ligação
/
Mapeamento Cromossômico
/
Fibrose Cística
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article