[Comparative molecular field analysis (CoMFA) of allylamine antimycotics].
Yao Xue Xue Bao
; 32(8): 593-9, 1997 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-11596308
ABSTRACT
Active analog approach has been applied to determine the pharmacophoric conformations of the allylamine antimycotics. Comparative molecular field analysis (CoMFA) has been used to establish 3D-QSAR of 48 allylamine antimycotics against six common human pathogenic fungi. Two different alignment rules were compared in the meantime. Five new synthetic compounds have been successfully employed to examine the predictive abilities of the CoMFA models against Trichophyton mentagrophytes and Aspergillus fumigatus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Relação Quantitativa Estrutura-Atividade
/
Alilamina
/
Antifúngicos
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Ano de publicação:
1997
Tipo de documento:
Article