Biopharmaceutic influences on the anticholinergic effects of propantheline.
Clin Pharmacol Ther
; 18(4): 457-61, 1975 Oct.
Article
em En
| MEDLINE
| ID: mdl-1164826
ABSTRACT
With reduction of salivary flow rates as an index of anticholinergic response, 3 subjects manifested demonstrable effects shortly after ingestion of 15-mg doses of propantheline in conventional tablets. Ingestion of this dose i-mediately after a standardized breakfast substantially reduced the anticholinergic effects. In 1 subject, a dose-response relationship was noted after 15 mg and 30 mg doses under both fasting and fed conditions, but at each dose level the influence of food was clear. Administration of a 30-mg dose of propantheline in a commercially available "prolonged-acting" tablet induced little if any anticholinergic effects; in 2 subjects, marginal but fleeting indications of salivary suppression were noted about 4 hr after ingestion, while no effects were observed in the third subject (even after 2 "prolonged-acting" tablets).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Parassimpatolíticos
/
Propantelina
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1975
Tipo de documento:
Article