Inhibition of tumor growth by plasminogen-related protein-B.
Anticancer Res
; 21(4A): 2287-91, 2001.
Article
em En
| MEDLINE
| ID: mdl-11724284
ABSTRACT
BACKGROUND:
Various fragments of the fibrinolytic protein plasminogen can act as antiangiogenic factors and inhibit the growth of primary and metastatic tumors in mice. Plasminogen-related gene-B encodes a putative 9 kDa protein virtually identical to the plasminogen N-terminal activation peptide, a 77-amino acid motif that is liberated from the parent plasminogen molecule during conversion to the serine proteinase plasmin. Previous data have documented enhanced transcription of plasminogen-related gene-B in neoplastic tissues. MATERIALS ANDMETHODS:
We have tested the effects of recombinant versions of plasminogen-related protein-B and the plasminogen N-terminal activation peptide on the growth of tumors in mice, employing murine tumor cell lines implanted subcutaneously.RESULTS:
The recombinant plasminogen-related protein-B significantly inhibited the growth of primary tumors in mice, while recombinant plasminogen N-terminal activation peptide elicited only a slight inhibition of tumor growth.CONCLUSION:
These data suggest that plasminogen-related protein-B may have utility as a novel cancer therapeutic.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasminogênio
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article