Intolerance to neuroleptics and susceptibility for malignant hyperthermia in a patient with proximal myotonic myopathy (PROMM) and schizophrenia.
Neuromuscul Disord
; 12(1): 31-5, 2002 Jan.
Article
em En
| MEDLINE
| ID: mdl-11731282
ABSTRACT
We report a patient with proximal myotonic myopathy who was treated with neuroleptics because of exacerbating schizophrenia. Under therapy with fluanxol, the patient developed muscle stiffness and oculogyric cramps. Treatment with both amisulpride and olanzapine lead to markedly elevated serum creatine kinase levels. An in-vitro contracture test was positive for halothane. Thus, in patients with all kinds of multisystemic myotonic myopathies, a susceptibility for malignant hyperthermia and intolerance towards neuroleptics should be taken into account.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Antipsicóticos
/
Transtornos Miotônicos
/
Flupentixol
/
Hipertermia Maligna
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article