Cutaneous sclerosing Pacinian-like perineurioma.
Histopathology
; 39(5): 498-502, 2001 Nov.
Article
em En
| MEDLINE
| ID: mdl-11737308
ABSTRACT
AIMS:
The term perineurioma has been used to designate a variety of clinically and histologically different proliferations of perineurial cells based on immunohistochemical and/or ultrastructural characterization. There are two different groups of neoplasms derived from perineurial cells extraneural or soft tissue perineuriomas, and intraneural perineuriomas. Recently, a sclerosing variant of cutaneous perineurioma has been described. METHODS ANDRESULTS:
We report a case of a cutaneous form of perineurioma, combining features of the intraneural and sclerosing varieties, as well as showing a Pacinian pattern of growth. In order to assess the neoplastic nature of the lesion, we performed fluorescence in-situ hybridization (FISH) analysis using a probe which maps to the chromosome band 22q11 and 22q13, allowing us to show deletion or loss of one chromosome 22 in the tumour cells.CONCLUSIONS:
This case may be considered a new variant of perineurioma with Pacinian-like features, for which we propose the designation 'sclerosing Pacinian-like perineurioma'.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Neoplasias de Bainha Neural
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article