Sequence of the cloned gene for the constant region of murine gamma 2b immunoglobulin heavy chain.
Science
; 206(4424): 1303-6, 1979 Dec 14.
Article
em En
| MEDLINE
| ID: mdl-117549
ABSTRACT
The complete nucleotide sequence of the gamma 2b constant region gene cloned from BALB/c liver DNA is reported. The sequence of approximately 1870 base pairs includes the 5' flanking, 3' untranslated, and 3' flanking regions and three introns. The C gamma 2b coding region is divided by these introns into four segments corresponding to the homology domains and hinge region of the protein. The introns separating the hinge from the CH2 domain and the CH2 from the CH3 domain are small (106 and 119 base pairs). A larger intervening sequence of 314 base pairs separates the CH1 and hinge regions. The stretch of DNA comprising this large intron plus the hinge shows a strong homology with the other CH domains.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulinas
/
Regiões Constantes de Imunoglobulina
/
Cadeias gama de Imunoglobulina
/
Cadeias Pesadas de Imunoglobulinas
/
Genes
Limite:
Animals
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article