The involvement of class Ib molecules in the host response to infection with Salmonella and its relevance to autoimmunity.
Microbes Infect
; 3(14-15): 1249-59, 2001.
Article
em En
| MEDLINE
| ID: mdl-11755413
ABSTRACT
Class I molecules with limited polymorphism have been implicated in the host response to infectious agents. Following infection with Salmonella typhimurium, mice develop a CD8+ CTL response that specifically recognizes bacteria infected cells. An immunodominant component of the CTL response recognizes a peptide epitope derived from the Salmonella GroEL molecule that is presented by the non-polymorphic MHC class Ib molecule Qa-1. T cells recognizing the bacterial peptide also cross-recognize a homologous peptide from the mammalian hsp60 molecule. Since Qa-1 has a functional equivalent in humans, this observation may be relevant not only to the host response involved in clearing infection but also in understanding the link between infection with Gram-negative pathogens and autoimmune disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Salmonella
/
Salmonelose Animal
/
Linfócitos T Citotóxicos
/
Antígenos de Histocompatibilidade Classe I
/
Autoimunidade
/
Apresentação de Antígeno
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article