Tandem chain extension-aldol reaction: syn selectivity with a zinc enolate.
Org Lett
; 3(26): 4169-71, 2001 Dec 27.
Article
em En
| MEDLINE
| ID: mdl-11784169
ABSTRACT
A tandem chain extension-aldol reaction was developed in which beta-keto esters are transformed to alpha-substituted-gamma-keto esters in an efficient zinc-mediated, one-pot reaction. The diastereoselectivity of the reaction ranged from good to excellent with syn stereochemistry observed for beta-keto ester and amide substrates and anti-stereochemistry observed for a beta-keto imide. [reaction see text]
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Zinco
/
Aldeídos
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article