The role of a bioengineered artificial kidney in renal failure.
Ann N Y Acad Sci
; 944: 284-95, 2001 Nov.
Article
em En
| MEDLINE
| ID: mdl-11797678
ABSTRACT
Renal failure continues to carry substantial burden of morbidity and mortality in both acute and chronic forms, despite advances in transplantation and dialysis. There is evidence to suggest that the kidney has metabolic, endocrine, and immune effects transcending its filtration functions, even beyond secretion of renin and erythropoietin. Our laboratory has developed experience in the tissue culture of renal parenchymal cells, and has now been able to demonstrate the metabolic activity of these cells in an extracorporeal circuit recapitulating glomerulotubular anatomy. We have observed active transport of sodium, glucose, and glutathione. We describe the design and initial preclinical testing of the bioartificial kidney, as well as future directions of our research.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Órgãos Bioartificiais
/
Insuficiência Renal
/
Rins Artificiais
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article