Redox refunctionalization of steroid spiroketals. Structure correction of ritterazine M.
Org Lett
; 4(3): 313-6, 2002 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-11820867
ABSTRACT
The structure of the North spiroketal moiety of ritterazine M has been corrected from 1a to 1b. This was accomplished by comparison of published spectra of the natural product with five synthetic spiroketal-alcohols. Synthesis of these models was efficiently accomplished by reductive cleavage of the spiroketal and Sharpless asymmetric dihydroxylation of an isopentyl, methyl 1,1-disubstituted olefin, followed by Suarez iodine[III] oxidative spirocyclization of monoprotected 1 degree,3 degree 1,2 diols.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Espiro
/
Esteroides
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article