DNA polymerase beta.
Int J Biochem Cell Biol
; 34(4): 321-4, 2002 Apr.
Article
em En
| MEDLINE
| ID: mdl-11854030
ABSTRACT
Mammalian DNA polymerase beta(beta-pol) is a single polypeptide chain enzyme of 39kDa. beta-pol has enzymatic activities appropriate for roles in base excision repair and other DNA metabolism events involving gap-filling DNA synthesis. Many crystal structures of beta-pol complexed with dNTP and DNA substrates have been solved, and mouse fibroblast cell lines deleted in the beta-pol gene have been examined. These approaches have enhanced our understanding of structural and functional aspects of beta-pol's role in protecting genomic DNA.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Polimerase beta
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article