Localisation of C reactive protein in infarcted tissue sites of multiple organs during sepsis.
J Clin Pathol
; 55(2): 152-3, 2002 Feb.
Article
em En
| MEDLINE
| ID: mdl-11865015
ABSTRACT
This report hypothesises an active role for the acute phase protein, C reactive protein (CRP), in local inflammatory reactions. This was studied in infarction sites from liver and kidney in a patient who died as a result of multiple complications after cholecystectomy. In this patient, a general acute phase protein reaction was induced, with an increase in plasma CRP. In infarction sites of kidney and liver, colocalisation of CRP and activated complement were found, whereas non-infarct sites were negative for CRP and complement. These results suggest that CRP directly participates in local inflammatory processes, possibly via complement activation, after binding of a suitable ligand.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína C-Reativa
/
Sepse
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Infarto
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article