Thrombotic stroke associated with the use of porcine factor VIII in a patient with acquired haemophilia.
Haemophilia
; 8(1): 56-8, 2002 Jan.
Article
em En
| MEDLINE
| ID: mdl-11886466
ABSTRACT
Porcine factor VIII (pFVIII), which is used to control bleeding in patients with congenital or acquired haemophilia who have high-titre neutralizing antibodies to human FVIII, is not known to increase the risk of arterial or venous thrombosis. We have recently encountered a patient with acquired haemophilia who developed a thrombotic left middle cerebral artery distribution stroke while being treated with pFVIII. To our knowledge, this is the first such reported thrombotic event. We speculate that platelet activation induced by pFVIII may have contributed to thrombosis and suggest that pFVIII be used with caution in elderly patients with pre-existing cardiovascular risk factors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator VIII
/
Trombose Intracraniana
/
Hemofilia A
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Aged
/
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article