Practical aspects of discovery pathology.
Toxicol Pathol
; 30(1): 8-10, 2002.
Article
em En
| MEDLINE
| ID: mdl-11890479
ABSTRACT
Pathologists are uniquely qualified to play a central role in driving drug discovery and development programs by 1) establishing disease models to assess potential therapies, 2) characterizing modifications in the disease state in response to therapies, 3) characterizing toxicologic mechanisms and responses to drug candidates, and 4) facilitating multidisciplinary efforts to monitor for the clinical occurrence, progression, and reversibility of adverse events. Such nontraditional deployment of resources must, to be viable, produce benefits to the pharmaceutical industry comparable to those of more conventional activities such as delivery of data in nonclinical safety studies. Additionally, benefits must be tangible from standpoints such as time savings or improved quality of research decisions, manifesting as either program acceleration or improved candidate survival.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Patologia
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article