APC, signal transduction and genetic instability in colorectal cancer.
Nat Rev Cancer
; 1(1): 55-67, 2001 Oct.
Article
em En
| MEDLINE
| ID: mdl-11900252
ABSTRACT
Colorectal cancer arises through a gradual series of histological changes, each of which is accompanied by a specific genetic alteration. In general, an intestinal cell needs to comply with two essential requirements to develop into a cancer it must acquire selective advantage to allow for the initial clonal expansion, and genetic instability to allow for multiple hits in other genes that are responsible for tumour progression and malignant transformation. Inactivation of APC--the gene responsible for most cases of colorectal cancer--might fulfil both requirements.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Transdução de Sinais
/
Transativadores
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Aberrações Cromossômicas
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Genes APC
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Repetições de Microssatélites
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article