N-linked oligosaccharide chains of Sendai virus fusion protein determine the interaction with endoplasmic reticulum molecular chaperones.
FEBS Lett
; 513(2-3): 153-8, 2002 Feb 27.
Article
em En
| MEDLINE
| ID: mdl-11904141
ABSTRACT
The selectivity and individual roles of the N-linked oligosaccharide chains of Sendai virus fusion protein (F protein) in the interaction with endoplasmic reticulum molecular chaperones were investigated by analyses of transient expression of single N-glycosylation mutants and sequential immunoprecipitation. We demonstrated differential interactions depending on the location of the N-linked oligosaccharide chain, and showed that these interactions were correlated with the folding and transport of F proteins. Moreover, mutant F proteins that lacked the specific N-linked oligosaccharide chains required for disulfide bond formation showed increased association with ERp57.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
/
Proteínas Virais de Fusão
/
Chaperonas Moleculares
/
Retículo Endoplasmático
Limite:
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article