Cefepime-induced neurotoxicity: an underestimated complication of antibiotherapy in patients with acute renal failure.
Intensive Care Med
; 28(2): 214-7, 2002 Feb.
Article
em En
| MEDLINE
| ID: mdl-11907668
ABSTRACT
OBJECTIVES:
To describe five new cases of life-threatening cefepime-induced neurotoxicity observed in a 2-year period.SETTING:
A university intensive care unit. PATIENTS Five patients recently treated with cefepime, admitted for seizures and coma. All suffered from acute renal failure, induced by sepsis and combined aminoside therapy, or by cefepime itself in one case.INTERVENTIONS:
All patients underwent hemodialysis, which led to complete neurological improvement in four of them. One patient remained comatose and subsequently died. MEASUREMENTS Blood and CSF cefepime levels were measured by high performance liquid chromatography before and after hemodialysis.CONCLUSION:
The frequency of cefepime-induced neurotoxicity is probably underestimated. Monitoring of renal function and close neurological survey in treated patients should allow an early diagnosis of this complication. Urgent hemodialysis seems the best therapeutic method to obtain a rapid neurological improvement.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cefalosporinas
/
Injúria Renal Aguda
/
Sistema Nervoso
Tipo de estudo:
Screening_studies
Limite:
Adolescent
/
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article