Synthesis of some new antianemics I. Iron pullulan complexes of pharmaceutical interest.
Pharmazie
; 57(3): 155-8, 2002 Mar.
Article
em En
| MEDLINE
| ID: mdl-11933841
ABSTRACT
First experiments were performed in order to obtain a polynuclear iron(III) complex with pullulan, which could be applied in therapy of sideropenic anemia. Complete synthesis of the complex can be realized with oligomers of depolymerized pullulan at an average molar mass 8000-10,000 g.mol-1. Maximum iron contents of 51.4 mg.cm-3 is effected by pullulan depolymerizates (Mw approximately 9000 g.mol-1, [eta] = 0.085 dl.g-1) at 130 degrees C for 240 min, at pH = 10.5 and at an initial mass ratio Fe/ligand of 13. The effected concentrations and complex stability respond to requirements of pharmacological application of parenteral antianemic preparations.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glucanos
/
Anemia
/
Ferro
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article