Synthesis of an influenza neuraminidase inhibitor intermediate via a highly diastereoselective coupling reaction.
Org Lett
; 4(9): 1427-30, 2002 May 02.
Article
em En
| MEDLINE
| ID: mdl-11975595
ABSTRACT
[reaction see text]. A highly diastereoselective coupling reaction between TBSOP (3) and trityl sulfenimine 4 was developed which provided influenza neuraminidase inhibitor intermediate 7 in 80% yield and >99% de after crystallization. The reaction was shown to be reversible with the high diastereoselectivity resulting from a favorable H-bonding interaction in the major diastereomer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Orthomyxoviridae
/
Pirrolidinas
/
Inibidores Enzimáticos
/
Neuraminidase
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article