The effect of methotrexate on actin and invasiveness of hepatoma Morris 5123 cells in culture.
Acta Biochim Pol
; 48(4): 1051-60, 2001.
Article
em En
| MEDLINE
| ID: mdl-11995967
ABSTRACT
Monomeric (G), total (T) and filamentous (F) actin and the state of actin polymerisation (FG) were determined and actin filaments were visualized in hepatoma Morris 5123 cells cultured in the presence of methotrexate (MTX) at various concentration. The exposure of the cells to this drug resulted in a decrease of total and polymerised actin in cytoplasm and in some changes in actin filament organization. This coincided with a decrease of the cells' ability to migrate through Matrigel coated filters and with inhibition of tumour formation after reimplantation of the methotrexate treated cells to experimental rats.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metotrexato
/
Actinas
/
Carcinoma Hepatocelular
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article