Stereocontrolled [3 + 2] annulations with arene chromium tricarbonyl complexes: construction of spirocyclic compounds related to fredericamycin A.
Org Lett
; 4(12): 1981-4, 2002 Jun 13.
Article
em En
| MEDLINE
| ID: mdl-12049497
ABSTRACT
[reaction see text] An efficient method has been developed for the stereocontrolled construction of polycyclic and spirocyclic compounds, including the spirocyclic core of the antitumor agent fredericamycin A. The strategy involves a one-pot aldol addition/Brook rearrangement/cyclization sequence beginning from arene chromium tricarbonyl complexes and can formally be described as a [3 + 2] annulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Espiro
/
Compostos de Cromo
/
Isoquinolinas
/
Antibióticos Antineoplásicos
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article