Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer.
Nat Genet
; 31(3): 301-5, 2002 Jul.
Article
em En
| MEDLINE
| ID: mdl-12053177
ABSTRACT
We have found that EEF1A2, the gene encoding protein elongation factor EEF1A2 (also known as eEF-1 alpha 2), is amplified in 25% of primary ovarian tumors and is highly expressed in approximately 30% of ovarian tumors and established cell lines. We have also demonstrated that EEF1A2 has oncogenic properties it enhances focus formation, allows anchorage-independent growth and decreases the doubling time of rodent fibroblasts. In addition, EEF1A2 expression made NIH3T3 fibroblasts tumorigenic and increased the growth rate of ES-2 ovarian carcinoma cells xenografted in nude mice. Thus, EEF1A2 and the process of protein elongation are likely to be critical in the development of ovarian cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Fator 1 de Elongação de Peptídeos
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article