Diversity considerations in HIV-1 vaccine selection.
Science
; 296(5577): 2354-60, 2002 Jun 28.
Article
em En
| MEDLINE
| ID: mdl-12089434
ABSTRACT
Globally, human immunodeficiency virus-type 1 (HIV-1) is extraordinarily variable, and this diversity poses a major obstacle to AIDS vaccine development. Currently, candidate vaccines are derived from isolates, with the hope that they will be sufficiently cross-reactive to protect against circulating viruses. This may be overly optimistic, however, given that HIV-1 envelope proteins can differ in more than 30% of their amino acids. To contend with the diversity, country-specific vaccines are being considered, but evolutionary relationships may be more useful than regional considerations. Consensus or ancestor sequences could be used in vaccine design to minimize the genetic differences between vaccine strains and contemporary isolates, effectively reducing the extent of diversity by half.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Filogenia
/
Variação Genética
/
HIV-1
/
Vacinas contra a AIDS
Limite:
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article