The first successful base-promoted isomerization of propargyl amides to chiral ynamides. Applications in ring-closing metathesis of ene-ynamides and tandem RCM of diene-ynamides.
Org Lett
; 4(14): 2417-20, 2002 Jul 11.
Article
em En
| MEDLINE
| ID: mdl-12098261
ABSTRACT
[reaction see text] A highly useful sequence of reactions is described here. These reactions consist of the first successful base-induced isomerizations of propargyl amides to chiral ynamides, applications of these novel ynamides in ring-closure metathesis leading to chiral 2-amidodienes useful for Diels-Alder cycloadditions, and the first successful tandem RCM of diene-ynamides.
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01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article