A double-blind placebo-controlled trial of topiramate treatment for essential tremor.
Neurology
; 59(1): 132-4, 2002 Jul 09.
Article
em En
| MEDLINE
| ID: mdl-12105323
ABSTRACT
The safety and efficacy of topiramate (400 mg/d or maximum tolerated dose) as monotherapy or adjunctive treatment of essential tremor were investigated in a placebo-controlled, crossover study (n = 24). Topiramate resulted in significantly greater reductions from baseline based on normalized scores for a clinical rating of tremor location/severity, specific motor tasks/functional disabilities, and tremor-resultant functional disabilities. Most common adverse events were appetite suppression/weight loss and paresthesias.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tremor Essencial
/
Frutose
/
Anticonvulsivantes
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article