Effect of a nonsedative dose of propofol on memory for aversively loaded information in rats.
Anesthesiology
; 97(2): 447-53, 2002 Aug.
Article
em En
| MEDLINE
| ID: mdl-12151936
ABSTRACT
BACKGROUND:
The effects of propofol on memory for aversive information are not well determined. The authors evaluated the effects of a minimal nonsedative dose of propofol or midazolam on memory in rats, using an apparatus composed of two compartments a large bright anxiogenic one and a small dark neutral one.METHODS:
Groups of rat received propofol (9 mg/kg, intraperitoneally) or midazolam (3 mg/kg). Anxiety was assessed in rats placed in the anxiogenic compartment as the time before the animals entered the neutral compartment. Memory for an aversive event was assessed in rats placed in the anxiogenic compartment as the time to enter the neutral one where they previously experienced foot shocks (fear conditioning). To assess the memory for a nonaversive event, rats were placed in the neutral compartment with no shocks (preexposure). The following day, rats were placed in it and they experienced foot shocks. As a result of the preexposure, rats exhibit less fear to enter it.RESULTS:
Propofol and midazolam increased the time to enter the neutral compartment. Propofol or midazolam was given to rats before experiencing foot shocks in the neutral compartment. When later tested, the time to enter it was decreased. Propofol or midazolam was given to rats before the preexposure to the neutral compartment. When later tested, the latency to enter it was not modified by the preexposure.CONCLUSIONS:
Propofol and midazolam impaired memory for aversive and for nonaversive experiences at equianxiolytic doses that do not produce locomotor impairment in rats.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Midazolam
/
Propofol
/
Anestésicos Intravenosos
/
Reação de Fuga
/
Memória
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article