CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?
Sci STKE
; 2002(144): pe35, 2002 Aug 06.
Article
em En
| MEDLINE
| ID: mdl-12165654
ABSTRACT
T cells require dual stimulation to become activated. When T cells encounter antigen-presenting cells, both the T cell receptor (TCR) and the CD28 coreceptor are ligated and activated. Michel and Acuto discuss how the adaptor SLP-76, which is recruited to the activated TCR complex, and the Rho family guanosine triphosphatase exchanger Vav-1, which is recruited by the CD28 receptor and TCR, may form a macromolecular complex that results in T cells activation. Vav-1 may serve as a central integrator between CD28 signaling and TCR signaling through its indirect effects on phosphoinositide 3-kinase-dependent signaling.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Ativação Linfocitária
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Receptores de Antígenos de Linfócitos T
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Transdução de Sinais
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Proteínas Proto-Oncogênicas
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Antígenos CD28
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Proteínas de Ciclo Celular
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article