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Est1p as a cell cycle-regulated activator of telomere-bound telomerase.
Taggart, Andrew K P; Teng, Shu-Chun; Zakian, Virginia A.
Afiliação
  • Taggart AK; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Science ; 297(5583): 1023-6, 2002 Aug 09.
Article em En | MEDLINE | ID: mdl-12169735
In Saccharomyces cerevisiae, the telomerase components Est2p, TLC1 RNA, Est1p, and Est3p are thought to form a complex that acts late during chromosome replication (S phase) upon recruitment by Cdc13p, a telomeric DNA binding protein. Consistent with this model, we show that Est1p, Est2p, and Cdc13p are telomere-associated at this time. However, Est2p, but not Est1p, also binds telomeres before late S phase. The cdc13-2 allele has been proposed to be defective in recruitment, yet Est1p and Est2p telomere association persists in cdc13-2 cells. These findings suggest a model in which Est1p binds telomeres late in S phase and interacts with Cdc13p to convert inactive, telomere-bound Est2p to an active form.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Ciclo Celular / Telômero / Telomerase / Proteínas de Saccharomyces cerevisiae / Proteínas de Ligação a Telômeros Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2002 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Ciclo Celular / Telômero / Telomerase / Proteínas de Saccharomyces cerevisiae / Proteínas de Ligação a Telômeros Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2002 Tipo de documento: Article