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The T-lineage-affiliated CD2 gene lies within an open chromatin environment in acute promyelocytic leukemia cells.
Grimwade, David; Outram, Susan V; Flora, Rajinder; Ings, Stuart J; Pizzey, Arnold R; Morilla, Ricardo; Craddock, Charles F; Linch, David C; Solomon, Ellen.
Afiliação
  • Grimwade D; Division of Medical and Molecular Genetics, Guy's, King's and St. Thomas' School of Medicine, London SE1 9RT, UK. david.grimwade@kcl.ac.uk
Cancer Res ; 62(16): 4730-5, 2002 Aug 15.
Article em En | MEDLINE | ID: mdl-12183432
The nature of hemopoietic progenitors subject to leukemic transformation in acute myeloid leukemia (AML) has not been clearly defined. To address this issue, we have used DNase I hypersensitivity assays to study the chromatin structure surrounding the T-lineage-affiliated CD2 gene in the acute promyelocytic subtype of AML (APL). Upstream and downstream flanking regions of CD2 were found to be hypersensitive to DNase I in primary APL blasts, with an identical pattern of hypersensitive sites to those detected in cells of T-lineage. All of the sites were confirmed to be inaccessible to DNase I in B-lineage leukemia cells. The demonstration of T-cell-associated chromatin features in primary APL blasts has implications for the origin of APL that may arise in more primitive progenitors than previously considered to be the case.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatina / Linfócitos T / Leucemia Promielocítica Aguda / Antígenos CD2 Limite: Humans Idioma: En Ano de publicação: 2002 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatina / Linfócitos T / Leucemia Promielocítica Aguda / Antígenos CD2 Limite: Humans Idioma: En Ano de publicação: 2002 Tipo de documento: Article