New antipsychotic agents for schizophrenia: pharmacokinetics and metabolism update.
Curr Opin Investig Drugs
; 3(7): 1073-80, 2002 Jul.
Article
em En
| MEDLINE
| ID: mdl-12186270
ABSTRACT
The so-called atypical antipsychotics undergo extensive metabolism, except for amisulpride, which is substantially excreted unchanged. Risperidone is oxidized by CYP2D6/CYP3A4 and iloperidone is reduced by cytosolic enzymes, although CYP1A2, CYP2E1 and CYP3A4 are involved as well. Olanzapine is both conjugated and oxidized (mainly by CYP1A2), while quetiapine and zotepine primarily undergo CYP3A4-mediated oxidation. Ziprasidone pathways include aldehyde oxidase-mediated reduction and CYP3A4-mediated oxidation. The main metabolites of risperidone, zotepine and possibly perospirone and ziprasidone contribute to the parent drug's effect. Information is limited, however, on some promising antipsychotics in the pipeline.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Antipsicóticos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article