Ontogenetic study of the effects of energetic nutrients on amino acid metabolism of rat cerebral cortex.
Neurochem Res
; 27(6): 513-8, 2002 Jun.
Article
em En
| MEDLINE
| ID: mdl-12199157
ABSTRACT
We studied the effect of various energetic nutrients on metabolism of L-[U-14C]leucine and [1-14C]glycine in cerebral cortex of rats at different ages. At gestational age, glucose and lactate stimulated protein synthesis from L-[U-14C]leucine and [1-14C]glycine and from L-[U-14C]leucine, respectively; glucose, beta-OH-butyrate and lactate stimulated lipid synthesis from L-[U-14C]leucine. At 10 days of age, glucose, mannose, and fructose stimulated protein synthesis, and glucose and mannose stimulated oxidation to CO2 as well as lipid synthesis from L-[U-14C]leucine. In adult rats, glucose, mannose, and fructose stimulated protein synthesis from L-[U-14C]leucine and [1-14C]glycine; glutamine also markedly decreased the oxidation of L-[U-14C]leucine and [1-14C]glycine in 10-day-old and adult rats.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
/
Metabolismo Energético
/
Aminoácidos
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article