[Abnormal expression of the FHIT gene in human primary gastrointestinal cancers].
Hunan Yi Ke Da Xue Xue Bao
; 25(4): 331-3, 2000 Aug 28.
Article
em Zh
| MEDLINE
| ID: mdl-12205991
OBJECTIVE: To evaluate the relationship between FHIT gene and gastrointestinal cancers. METHODS: Matched normal and cancerous tissues from 26 patients with primary gastric carcinoma and 30 patients with colorectal carcinoma were analysed by nested polymerase chain reaction(RT-PCR) and direct sequencing of the products. RESULTS: Seven of 26(26.9%) gastric cancer tissues and eight of 30(26.7%) colorectal cancer tissues expressed aberrant FHIT transcripts, but no aberrant FHIT transcript was observed in all the matched normal tissues. Sequence analysis of the aberrant transcripts of 2 gastric cancer tissues(G8T, G25T) and 2 colorectal cancer tissues(C5T, C26T) confirmed the absence of 1 to 3 exons of FHIT gene. CONCLUSIONS: The expression of aberrant FHIT transcripts is common and tumor-specific in gastrointestinal cancers and abnormalities of FHIT gene may be associated with gastrointestinal tumorigenesis.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Neoplasias do Colo
/
Hidrolases Anidrido Ácido
/
Proteínas de Neoplasias
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2000
Tipo de documento:
Article