Thrombomodulin Ala455Val dimorphism is not associated with pre-eclampsia in Australian and New Zealand women.
Gynecol Obstet Invest
; 54(1): 43-5, 2002.
Article
em En
| MEDLINE
| ID: mdl-12297717
ABSTRACT
Thrombomodulin plays an important role in thromboresistance. A common mutation of the gene at amino acid 455 producing valine instead of alanine has been implicated as being a risk factor in myocardial infarction and chronic heart disease. However, its link with pre-eclampsia remains controversial. This report explores the Ala455Val point mutation in 280 women as a predictor of pre-eclampsia with the conclusion that in this regard, the dimorphism is essentially neutral.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Pré-Eclâmpsia
/
Trombomodulina
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Pregnancy
País/Região como assunto:
Oceania
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article