Antioxidant properties of MDL and MMDL, two nicergoline metabolites, during chronic administration of haloperidol.
Eur J Pharmacol
; 453(1): 69-73, 2002 Oct 18.
Article
em En
| MEDLINE
| ID: mdl-12393061
ABSTRACT
We evaluated the effects of 10-alpha-methoxy-9,10-dihydrolysergol (MDL) and 1-methyl-10-alpha-methoxy-9,10-dihydrolysergol (MMDL), two nicergoline metabolites, during chronic treatment with haloperidol in rats. Haloperidol induced a significant decrease in the glutathione (GSH) content in selected areas of the brain and in the liver. Prolonged administration of MDL, MMDL or nicergoline antagonized the haloperidol-induced GSH decrease. Lipid peroxidation in the cortex and striatum was suppressed by MDL, MMDL or nicergoline administration. Our results show that MDL, MMDL and nicergoline have antioxidant activity, preventing not only GSH depletion but also lipid peroxidation. These observations suggest beneficial properties of MDL and MMDL in the treatment of neuroleptic-induced side effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Haloperidol
/
Nicergolina
/
Antioxidantes
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article