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Development of the coronary vessel system.
Reese, David E; Mikawa, Takashi; Bader, David M.
Afiliação
  • Reese DE; Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY, USA.
Circ Res ; 91(9): 761-8, 2002 Nov 01.
Article em En | MEDLINE | ID: mdl-12411389
Formation of the coronary vessels is a fundamental event in heart development. Congenital abnormalities in the coronary system can have major deleterious effects on heart function. It is also possible that subtle variation in the patterning of coronary vessels has significant but uncharacterized effects on myocardial structure and function. In addition, generation of the coronary vascular system represents a complex system for analysis of regulation of cell fate determination, cell and epithelial migration, epithelial/mesenchymal transition, and patterning of a complex three-dimensional structure. In this review, we present the descriptive embryology of this process as well as the recent data that shed light on the unique developmental mechanisms underlying generation of coronary vessels. This review also attempts to identify areas where additional research is needed and highlights the questions that must be answered for a meaningful understanding of coronary vessel development.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasos Coronários / Organogênese Limite: Animals / Humans Idioma: En Ano de publicação: 2002 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasos Coronários / Organogênese Limite: Animals / Humans Idioma: En Ano de publicação: 2002 Tipo de documento: Article