[beta 2-adrenoceptor polymorphism and effect of inhaled beta 2-stimulant (procaterol) on airway resistance measured by body plethysmography in healthy volunteers].
Nihon Kokyuki Gakkai Zasshi
; 40(8): 637-43, 2002 Aug.
Article
em Ja
| MEDLINE
| ID: mdl-12428391
ABSTRACT
This study was designed to evaluate, in healthy volunteers, differences of bronchodilator responsiveness to a beta 2-agonist between those with the Arg 16/Gly 16 allele and those with the Gly 16/Gly 16 allele at codon 16 of beta 2 adrenoceptor polymorphism. Peak flow and pulmonary functions were measured by body plethysmography after the inhalation of procaterol. In the Arg 16/Gly 16 group, the resulting acute increase of V 25 and acute decrease of airway resistance were greater, and the bronchodilator effect of a single inhaled beta 2-agonist was longer, than those observed in the Gly 16/Gly 16 group. The present study showed that a single inhalation of procaterol has a varying bronchodilator effect on healthy adults, depending on the genotype of beta 2 adrenoceptor polymorphism at codon 16.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Broncodilatadores
/
Resistência das Vias Respiratórias
/
Procaterol
/
Receptores Adrenérgicos beta 2
/
Agonistas Adrenérgicos beta
/
Pulmão
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Ja
Ano de publicação:
2002
Tipo de documento:
Article