SUT1 suppresses sec14-1 through upregulation of CSR1 in Saccharomyces cerevisiae.
FEMS Microbiol Lett
; 216(2): 165-70, 2002 Nov 05.
Article
em En
| MEDLINE
| ID: mdl-12435498
ABSTRACT
SUT1 constitutive expression in aerobiosis suppressed the ts phenotype of the sec14-1 mutation, restored growth of the sec14-null mutant and corrected the translocation defect of the vacuolar carboxypeptidase Y. Therefore SUT1 was shown to be a novel potent sec14-1 suppressor. Further, the hypoxic gene CSR1 (YLR380W), a Sec14 homolog, was upregulated upon SUT1 constitutive expression. In addition, SUT1 effects on both sec14-1 suppression and on free sterol composition were abolished in a csr1-null background, showing that this gene acts downstream of SUT1.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Saccharomyces cerevisiae
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Fatores de Transcrição
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Proteínas Fúngicas
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Proteínas de Transporte
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Proteínas de Saccharomyces cerevisiae
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Proteínas de Membrana
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article