The assessment of OPV vaccines by the monkey neurovirulence test: why and how to qualify the experts in histology of central nervous system.
Vaccine
; 21(1-2): 115-9, 2002 Nov 22.
Article
em En
| MEDLINE
| ID: mdl-12443669
ABSTRACT
Prior to batch release of oral poliovirus vaccines (OPV) for marketing purpose, the World Health Organisation (WHO) and European pharmacopoeia require a monkey neurovirulence test to be performed both by the manufacturer and the relevant National Control Laboratory (NCL) to assess vaccine safety as regards neurovirulence. Due to the subjectivity of histological examination and of neural lesions scoring, the French NCL has set up a proficiency testing procedure to qualify a new expert.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliomielite
/
Bioensaio
/
Vacina Antipólio Oral
/
Sistema Nervoso Central
/
Poliovirus
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article