Planar polarity and actin dynamics in the epidermis of Drosophila.
Nat Cell Biol
; 4(12): 937-44, 2002 Dec.
Article
em En
| MEDLINE
| ID: mdl-12447392
ABSTRACT
Dorsal closure is a morphogenetic process involving the coordinated convergence of two epithelial sheets to enclose the Drosophila melanogaster embryo. Specialized populations of cells at the edges of each epithelial sheet, the dorsal-most epidermal cells, emit actin-based processes that are essential for the proper enclosure of the embryo. Here we show that actin dynamics at the leading edge is preceded by a planar polarization of the dorsal-most epidermal cells associated with a reorganization of the cytoskeleton. An important consequence of this planar polarization is the formation of actin-nucleating centres at the leading edge, which are important in the dynamics of actin. We show that Wingless (Wg) signalling and Jun amino-terminal kinase (JNK) signalling have overlapping but different roles in these events.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Actinas
/
Polaridade Celular
/
Proteínas Quinases JNK Ativadas por Mitógeno
/
Drosophila melanogaster
/
Epiderme
/
Células Epidérmicas
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article