[Upper and lower neural tube defects: prevalence and association with illnesses and drugs]. / Defectos del tubo neural altos y bajos, prevalencia, y asociación con enfermedades y medicamentos.
Ginecol Obstet Mex
; 70: 443-50, 2002 Sep.
Article
em Es
| MEDLINE
| ID: mdl-12448053
ABSTRACT
OBJECTIVE:
To determine the prevalence of upper and lower neural tube defects and identify its association with the exposure to illnesses and drugs during pregnancy. MATERIAL ANDMETHODS:
This is a case-control study of 107 newborns with upper neural tube defects, 59 with lower neural tube defects, and 166 newborns without malformations, in 56,926 consecutive births between 1989 and 1997. The exposure was documented by a direct interview to the mother of those subject of study. The association was measured by the odds ratios, with confidence interval of 95%.RESULTS:
The prevalence of upper neural tube defects was of 1.9 for 1,000 newborn (alive or dead) and of lower neural tube defects of 1.0 for 1,000. The exposure to illnesses of less than a month of duration was associated with upper neural tube defects (OR = 3.11; IC = 1.34-7.39) the most important was flu; also the exposure to drugs (OR = 5.85; IC = 2.97-11.62), the most prominent was acetaminophen. These factors of risk were not associated with lower neural tube defects. The mother's occupation, illness of more than a month of duration and X-ray exposure were not associated with of upper and lower neural tube defects.CONCLUSIONS:
More studies are needed in the association among illnesses of less than a month of duration and drugs with upper neural tube defects. The different exposure frequencies between upper and lower neural tube defects suggest heterogeneity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Defeitos do Tubo Neural
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Idioma:
Es
Ano de publicação:
2002
Tipo de documento:
Article