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Dextran sulfate (Selesorb) plasma apheresis improves vascular changes in systemic lupus erythematosus.
Braun, Norbert; Jünger, Michael; Klein, Reinhild; Gutenberger, Sylvia; Guagnin, Michael; Risler, Teut.
Afiliação
  • Braun N; Sektion Nieren- und Hochdruckkrankheiten der Medizinische Klinik und Poliklinik, Tübingen, Germany. nbraun@uni-tuebingen.de
Ther Apher ; 6(6): 471-7, 2002 Dec.
Article em En | MEDLINE | ID: mdl-12460414
Apheresis has been effective as rescue therapy in patients with severe, therapy-resistant, systemic lupus erythematosus (SLE). Its benefit in patients with less severe but therapy-resistant SLE is not known. Dextran sulfate apheresis was applied as a rescue therapy for therapy-resistant vasculitic skin lesions in a 30 year old female patient with a 9 year history of SLE in combination with antiphospholipid syndrome and Raynaud's phenomenon. Partial remission was achieved after 9 immunoadsorption sessions, as documented by marked improvement of skin lesions and an increase of capillary density in the nailfold area. Further improvement was noted with maintenance therapy using mycophenolate mofetil. Dextran sulfate apheresis can be applied safely in patients with moderate therapy-resistant SLE disease activity when severe immunodeficiency and cytotoxic adverse effects should be avoided.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Remoção de Componentes Sanguíneos / Sulfato de Dextrana / Lúpus Eritematoso Sistêmico Limite: Adult / Female / Humans Idioma: En Ano de publicação: 2002 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Remoção de Componentes Sanguíneos / Sulfato de Dextrana / Lúpus Eritematoso Sistêmico Limite: Adult / Female / Humans Idioma: En Ano de publicação: 2002 Tipo de documento: Article