Synthesis, antitumor activity, molecular modeling, and DNA binding properties of a new series of imidazonaphthalimides.
J Med Chem
; 45(26): 5813-6, 2002 Dec 19.
Article
em En
| MEDLINE
| ID: mdl-12477366
ABSTRACT
A series of mono and bisintercalators based on the 5,8-dihydrobenz[de]imidazo[4,5-g]isoquinoline-4,6-dione system were synthesized and evaluated for growth inhibitory properties in several human cell lines. All target compounds showed activity in the micromolar range. Representative compounds were evaluated using UV--vis spectroscopy and viscosimetric determinations, showing that they behave as DNA intercalators. Molecular modeling techniques were used in order to rationalize the moderate activity observed for bisnaphthalimides.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Heterocíclicos de 4 ou mais Anéis
/
Substâncias Intercalantes
/
Naftalenos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article