[Pharmacokinetic study of CPT-11, SN-38 and SN-38 glucuronide in the ascites, plasma and bile after intraperitoneal administration of CPT-11].
Gan To Kagaku Ryoho
; 29(12): 2188-90, 2002 Nov.
Article
em Ja
| MEDLINE
| ID: mdl-12484033
ABSTRACT
We studied the pharmacokinetics of CPT-11 with intraperitoneal administration in a patient with a PTCD tube. The patient had advanced gastric cancer with peritoneal metastasis. CPT-11 was administrated in a dose of 40 mg and the intraperitoneal, plasma and bile levels of CPT-11, SN-38 and SN-38 glucuronide (SN-38 GLU) were measured periodically. The results showed that the periodical concentration pattern of CPT-11, SN-38 and SN-38 GLU in the bile was closely related to that of CPT-11 in the abdominal cavity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Camptotecina
/
Glucuronídeos
/
Antineoplásicos Fitogênicos
Limite:
Aged
/
Aged80
/
Humans
/
Male
Idioma:
Ja
Ano de publicação:
2002
Tipo de documento:
Article