[Introduction of the human recombinant angiogenin at the early stages of postnatal development inhibits the growth of mice]. / Vvedenie rekombinantnogo angiogenina cheloveka na rannikh stadiiakh postnatal'nogo ontogeneza tormozit rost myshei.
Ontogenez
; 33(6): 461-4, 2002.
Article
em Ru
| MEDLINE
| ID: mdl-12500555
ABSTRACT
We studied the influence of recombinant DNA containing the cloned angiogenin gene, plasmid DNA without angiogenin gene, and purified recombinant angiogenin injected to Tg8 mice at the age of two days on the body mass of 28- and 40-day old mice. The body mass of mice that were injected with the cloned angiogenin gene or purified angiogenin was less than in the control mice. The body mice of Tg8 mice injected with recombinant DNA containing the cloned angiogenin gene did not increase from day 2 to day 40, while in the mice with purified recombinant angiogenin and control mice it increased by 24 and 57%, respectively. These data suggest that the elevated level of angiogenin at the early developmental stages inhibits the increase of body mass. The effect we described as related, in al likelihood, to the known inhibitory effect of angiogenin on protein synthesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ribonuclease Pancreático
/
Crescimento
Limite:
Animals
/
Humans
/
Male
Idioma:
Ru
Ano de publicação:
2002
Tipo de documento:
Article